ABSTRACT
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Although the parotid gland is the most common site of involvement, other major salivary glands and the minor salivary glandsmost commonly of the palatealso can be involved. The management of mucoepidermoid carcinoma depends on the grade of the tumor and the adequacy of resection. We present the case of a 56-year-old female presenting a painless progressive cheek mass over 2 months. Imaging and fine-needle aspiration cytology provided the diagnosis of Mucoepidermoid carcinoma. A superficial parotidectomy was done, and the histopathology revealed a predominantly cystic tumor with a bilayered epithelium of oncocytic and basal cells. Moderate nuclear pleomorphism with infiltration of atypical squamous cells in few glandular cysts was seen. Special staining revealed the presence of intracellular mucin. A diagnosis of Warthin-like variant of MEC was made, based on these findings. After the surgical procedures, the patient is disease-free at 8 months of follow-up. The Warthin-like variant is a rare variant of MEC with fewer than 10 cases described in the English literature. Various differential diagnoses include the malignant transformation of Wartin tumor (WT), squamous metaplasia of WT, and metastasis from a distant primary. We emphasize the role of routine microscopy in identifying rare variants of common malignancies. Even though translocation studies are helpful in diagnosis, the typical histopathological findings should confirm it.
Subject(s)
Humans , Female , Middle Aged , Parotid Neoplasms/pathology , Carcinoma, Mucoepidermoid/pathology , Carcinoma, Mucoepidermoid/surgery , Carcinoma, Mucoepidermoid/therapyABSTRACT
We report on a patient who presented at our clinic with a growth of the right palate of twenty years duration. A biopsy of the area was performed and the lesion was diagnosed as low-grade mucoepidermoid carcinoma (MEC). Due to the size of the tumor, it was decided to begin treatment with radiotherapy followed by chemotherapy. Once the initial treatment was completed, the lesion was reevaluated and surgery followed by reconstruction was recommended. The Patient rejected the recommended treatment and opted to enrolled in a pain management, palliative care program.
Reportamos sobre un paciente que se presentó con un crecimiento del paladar derecho de veinte años de evolución. Se realizó una biopsia del área y se diagnosticó la lesión como carcinoma mucoepidermoide (MEC) bajo grado. Debido al tamaño del tumor, se decidió comenzar el tratamiento con radioterapia seguida de quimioterapia. Una vez que el tratamiento inicial se completó, la lesión fue reevaluada y se recomendó la cirugía seguida de reconstrucción. El paciente rechazó el tratamiento recomendado y optó por seguir un tratamiento de manejo del dolor, programa de cuidados paliativos.
Subject(s)
Humans , Male , Middle Aged , Carcinoma, Mucoepidermoid/diagnosis , Carcinoma, Mucoepidermoid/therapy , Paranasal Sinus Neoplasms/diagnosis , Paranasal Sinus Neoplasms/therapy , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Treatment RefusalABSTRACT
This report presents an extremely rare tumor and provides information to deal with such tumors; intraosseous mucoepidermoid carcinoma. It's pathogenesis is still unknown and is rare in children. The conservative surgical procedures result to metastasis. An 11 year old girl was referred for a nonpainful swelling in maxillary region. Central mucoepidermoid carcinoma was diagnosed by clinical and paraclinical examinations. The lining of maxillary sinus was considered to be the source of the tumor. Hemimaxillectomy and adjuvant I radiotherapy was performed as treatment option and patient was reported to be in good health. Early diagnosis and radical resection with adjuvant radiotherapy offered the best chance for eradication of this tumor and that essential to prevent local recurrence and late distant methastasis
Subject(s)
Humans , Female , Carcinoma, Mucoepidermoid/therapy , Mandibular Neoplasms/pathology , Mandibular Neoplasms/diagnosis , Mandibular Neoplasms/surgery , RecurrenceABSTRACT
Dentro del grupo de los tumores malignos epiteliales de las fosas nasales y antro maxilar, el carcinoma mucoepidermoide es el más raro. La participación orbitaria es frecuente y se ilustra con dos casos, uno con participación de la cavidad nasal y antro maxilar y el otro exclusivamente del antro maxilar. Las manifestaciones clínicas dependen de las alteraciones mecánicas musculares y la proptosis; las más frecuentes son: exoftalmo no reductible, disminución de la capacidad visual hasta llegar a la ceguera y deformación facial. La tomografía y resonancia nuclear magnética son muy útiles en el diagnóstico y pronóstico. El pronóstico es malo tanto para la función como para la vida. El tratamiento es eminenetemente quirúrgico, la radioterapia y quimioterapia son paliativos y con severas complicaciones deletéreas